diff --git a/.github/workflows/python-package.yml b/.github/workflows/python-package.yml
index 6921950..ada133c 100644
--- a/.github/workflows/python-package.yml
+++ b/.github/workflows/python-package.yml
@@ -92,6 +92,7 @@ jobs:
           CIBW_MANYLINUX_AARCH64_IMAGE: "manylinux_2_24"
           CIBW_TEST_EXTRAS: "tests"
           CIBW_TEST_COMMAND: nosetests {project}/tests -d
+          CIBW_TEST_SKIP: "*-macosx_arm64"
 
       - name: Upload Wheels
         uses: actions/upload-artifact@v2
diff --git a/setup.py b/setup.py
index 859cae2..434978a 100644
--- a/setup.py
+++ b/setup.py
@@ -1,4 +1,5 @@
 import os
+import re
 import sys
 import glob
 import subprocess
@@ -84,6 +85,12 @@ class CMakeBuild(build_ext):
                 ]
                 build_args += ["--config", cfg]
 
+        if sys.platform.startswith("darwin"):
+            # Cross-compile support for macOS - respect ARCHFLAGS if set
+            archs = re.findall(r"-arch (\S+)", os.environ.get("ARCHFLAGS", ""))
+            if archs:
+                cmake_args += ["-DCMAKE_OSX_ARCHITECTURES={}".format(";".join(archs))]
+
         # Set CMAKE_BUILD_PARALLEL_LEVEL to control the parallel build level
         # across all generators.
         if "CMAKE_BUILD_PARALLEL_LEVEL" not in os.environ: